Transmembrane channel-like 4 and 5 proteins at microvillar tips are potential ion channels and lipid scramblases
Seham Ebrahim, Ángela Ballesteros, W. S. Zheng, Shounak Mukherjee, Gaizun Hu, Wei-Hsiang Weng, Jonathan S. Montgomery, Yaw Agyemang, Runjia Cui, Willy W. Sun, Evan Krystofiak, Mark P. Foster, Marcos M. Sotomayor, Bechara Kachar
The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.
bioRxiv · Aug 22, 2024 · PreprintCell Biology