Bechara Kachar

Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus organization

This study identifies Pcdh20 as a POU2F3 target gene essential for tuft cell microvillus structure, showing its role in maintaining microvillar rigidity and organization.

Spontaneous calcium transients in hair cell stereocilia

This study detects spontaneous calcium transients in hair cell stereocilia using fluorescent sensors and microscopy, showing they originate from mechanoelectrical transduction channels and occur in multiple stereocilia regions.

Hemifusomes and Interacting Proteolipid Nanodroplets: Formation of a Novel Cellular Organelle Complex

The paper identifies a novel cellular organelle complex called hemifusomes through cryo-electron tomography, revealing their role in intraluminal vesicle biogenesis.

Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior

The paper identifies secretory cell types in placozoans involved in feeding, immunity, and behavior regulation using single-cell transcriptomics and imaging techniques.

The Dual Molecular Identity of Vestibular Kinocilia: Bridging Structural and Functional Traits of Primary and Motile Cilia

The paper identifies the kinocilium as a unique organelle with molecular features of both primary and motile cilia, showing it generates force in the hair bundle.

Hair Bundle Degeneration is a Key Contributor to Age-Related Vestibular Dysfunction

The paper identifies age-related molecular and cellular changes in vestibular hair cells that contribute to vestibular dysfunction by impairing mechanotransduction and hair bundle integrity.

Transmembrane channel-like 4 and 5 proteins at microvillar tips are potential ion channels and lipid scramblases

The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.

Dynamic coupling of cochlear inner hair cell intrinsic Ca2+ action potentials to Ca2+ signaling of non-sensory cells

The paper shows that immature inner hair cells in the cochlea have intrinsic Ca2+ action potentials that are bidirectionally coupled to ATP-dependent Ca2+ signaling in non-sensory cells.

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

This study identifies LMO7 as a hair cell protein localized to the cuticular plate, showing that its deficiency leads to structural defects and progressive hearing loss.