Wan Zheng

This study reveals the structure and function of the cytoplasmic lattice in mammalian eggs, showing it sequesters ubiquitination machinery and tubulin for use during early embryonic development.

This study reveals how TACO1 enhances mitochondrial translation efficiency by stabilizing tRNA and promoting ribosomal translocation, with implications for bacterial orthologs.

The paper identifies a novel non-motile dynein heavy chain subfamily, DNAHX, using cryo-EM and shows its evolutionary origin and structural features.

This study identifies a paracellular water secretion pathway in the lacrimal gland regulated by non-muscle myosin IIC, which modulates tight junction permeability and can be targeted for dry eye treatment.

The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.

This paper uses in-situ cryo-electron microscopy to determine high-resolution structures of mitochondrial respiratory supercomplexes in their native state, revealing their organization and dynamic processes.

This study identifies H2BC1 and H2AZ.2 as critical components of H2AK119ub nucleosomes, essential for Polycomb gene silencing.

iAChSnFR, a fluorescent indicator built from a bacterial periplasmic binding protein, reports acetylcholine with large, fast signals in mouse, fish, fly and worm preparations.