Author

Sigmund H. Hsu

The University of Texas Health Science Center at Houston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Ankush ChandraiD· 1 shared Antonio DonoiD· 1 shared Austin ArrigoiD· 1 shared Chuling ZhuangiD· 1 shared Dongqin ZhuiD· 1 shared Hui‐Wen LoiD· 1 shared Jay‐Jiguang ZhuiD· 1 shared Mariana K. NajjariD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ankush ChandraORCID

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1 paper

Recent·Most cited

Targeting tGLI1, a novel mediator of tumor therapeutic resistance, using Ketoconazole sensitizes glioblastoma to CDK4/6 therapy and Chemoradiation

Yu Pu Yang, Austin Arrigo, Ankush Chandra, Chuling Zhuang, Mariana K. Najjar, Munazza Samar Khan, Dongqin Zhu, Antonio Dono, Roy Ervin Strowd III, Nitin Tandon, Jay‐Jiguang Zhu, Sigmund H. Hsu, Yoshua Esquenazi, Michael David Chan, Hui‐Wen Lo

This paper identifies tGLI1 as a mediator of GBM resistance to CDK4/6 inhibitors and shows that ketoconazole sensitizes GBM to CDK4/6 therapy and chemoradiation.

bioRxiv · Feb 20, 2025 · PreprintCancer Biology