Author

Yu Pu Yang

Children's NationalORCID 0000-0002-4518-3299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexandros TzatsosiD· 1 shared Ankush ChandraiD· 1 shared Antonio DonoiD· 1 shared Austin ArrigoiD· 1 shared Aylar BabaeiiD· 1 shared Brian R. RoodiD· 1 shared C. Russell N. Cruz· 1 shared Chuling ZhuangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Alexandros TzatsosORCID

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2 papers

Recent·Most cited

Large-Scale Assessment of NF1 Single Amino Acid Variants as HLA Class I Neoantigens

Sung Yun Jung, Aylar Babaei, Alexandros Tzatsos, Junfeng R Ma, Yu Pu Yang, Wai Chin Chong, Huizhen Zhang, Richard T. Graham, C. Russell N. Cruz, Javad Nazarian, Brian R. Rood, Jianhua Yang, Chunchao Zhang

The paper evaluates NF1-derived single amino acid variants as HLA class I neoantigens using computational prediction and experimental validation, finding discrepancies between predictions and observed sequences.

bioRxiv · May 13, 2026 · PreprintImmunology

Targeting tGLI1, a novel mediator of tumor therapeutic resistance, using Ketoconazole sensitizes glioblastoma to CDK4/6 therapy and Chemoradiation

Yu Pu Yang, Austin Arrigo, Ankush Chandra, Chuling Zhuang, Mariana K. Najjar, Munazza Samar Khan, Dongqin Zhu, Antonio Dono, Roy Ervin Strowd III, Nitin Tandon, Jay‐Jiguang Zhu, Sigmund H. Hsu, Yoshua Esquenazi, Michael David Chan, Hui‐Wen Lo

This paper identifies tGLI1 as a mediator of GBM resistance to CDK4/6 inhibitors and shows that ketoconazole sensitizes GBM to CDK4/6 therapy and chemoradiation.

bioRxiv · Feb 20, 2025 · PreprintCancer Biology