SIPA1L2 controls trafficking and signaling of TrkB-containing amphisomes at presynaptic terminals
Maria Andres‐Alonso, Mohamed Raafet Ammar, Ioana Butnaru, Guilherme M. Gomes, Gustavo Acuña Sanhueza, Rajeev Raman, PingAn Yuanxiang, Maximilian Borgmeyer, Jeffrey Lopez‐Rojas, Syed Ahsan Raza, Nicola Brice, Torben Johann Hausrat, Tamar Macharadze, Silvia Diaz-Gonzalez, Mark B. L. Carlton, , Michael R. Kreutz
This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.
Nature Communications · Nov 29, 2019Peer-reviewedNeuroscience