Author

Martina Zenkner

Max Delbrück Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Erich E. WankeriD· 4 shared Christopher SeckeriD· 3 shared Eduardo Silva RamosiD· 3 shared Philipp TrepteiD· 3 shared Sabrina Golusik· 3 shared Stephanie Beetz· 3 shared Andranik IvanoviD· 2 shared Annett Boeddrich· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersSystems Biology

Erich E. WankerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space

Eduardo Silva Ramos, Annett Boeddrich, Christian Haenig, Philipp Trepte, Orchid Ammar, Christopher Secker, Oliver Popp, Andranik Ivanov, Brandon A. Keith, Rachel J. Harding, Franziska Schindler, Tomáš Koudelka, Leonard Roth, Nadine Scharek, Martina Zenkner, , Erich E. Wanker

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

bioRxiv · Apr 1, 2026 · PreprintCell Biology

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Julien Olivet, Jérémy Blavier, Simona Kostova, Sibusiso B. Maseko, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, , Erich E. Wanker

The paper presents an AI-guided pipeline for PPI drug discovery, identifying a SARS-CoV-2 inhibitor by combining experimental assays, machine learning, and virtual screening.

Molecular Systems Biology · Mar 11, 2024Peer-reviewedSystems Biology

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease

Annett Boeddrich, Christian Haenig, Nancy Neuendorf, Eric Blanc, Andranik Ivanov, Marieluise Kirchner, Philipp Schleumann, Irem Bayraktaroğlu, Matthias Richter, Christine Molenda, Anje Sporbert, Martina Zenkner, Sigrid Schnoegl, Christin Suenkel, Luisa‐Sophie Schneider, , Erich E. Wanker

This study identifies Arl8b as a potential biomarker for Alzheimer's disease by analyzing proteomic changes in 5xFAD mouse brain regions and CSF from AD patients.

Genome Medicine · Jul 19, 2023Peer-reviewedMolecular Biology

A quantitative mapping approach to identify direct interactions within complexomes

Philipp Trepte, Christopher Secker, Soon Gang Choi, Julien Olivet, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Marcel Sperling, Yang Wang, Tong Hao, Kerstin Spirohn, Jean‐Claude Twizere, Michael A. Calderwood, , Erich E. Wanker

The paper presents a framework combining two high-throughput interaction assays to distinguish direct from indirect protein interactions in complexes.

bioRxiv · Aug 25, 2021 · PreprintSystems Biology