Targeted and efficient AAV therapy for neuroblastoma via direct capsid-antibody coupling
Mirko Luoni, Serena Gea Giannelli, Stefano Parracino, Francesca Morosi, Elisa Ventura, Agostina Di Pizio, Sharon Muggeo, Angelo Iannielli, Tamara Canu, Tommaso Russo, Antonio Esposito, Fabio Pastorino, Vania Broccoli
This paper develops AAV-STITCH, a method to target neuroblastoma cells using anti-GD2 ScFv coupled to AAV capsids, showing selective transduction and tumor suppression in mouse models.
bioRxiv · Nov 12, 2025 · PreprintBioengineering