CellEKT: A robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors
Joel Rüegger, Berend Gagestein, Antonius P. A. Janssen, Alexandra Valeanu, Alger Lazo Mori, Marielle van der Peet, Michael S. Boutkan, Bogdan I. Florea, Alex A. Henneman, Remo Hochstrasser, Haiyan Wang, Paul Westwood, Andreas Topp, Patricia M. Gomez Barila, Jan Paul Medema, , Mario van der Stelt
CellEKT profiles cellular target engagement of kinase inhibitors using chemical proteomics to determine IC50 values across over 300 kinases and validate results with phosphoproteomics and NanoBRET.
Molecular & Cellular Proteomics · Apr 6, 2025Peer-reviewedCancer Biology