Author
F. Hoffmann-La Roche AGORCID 0000-0001-5092-7478Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Adrián Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza…·Jana Selent
The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.
Leire Borrega Roman, Bradley L. Hoare, Miroslav Kosar…·Dmitry B. Veprintsev
This paper develops a TR-FRET-based assay to measure ligand binding kinetics for CB1R and CB2R, finding that D77 enables accurate determination of on- and off-rates for various agonists and antagonists.
Joel Rüegger, Berend Gagestein, Antonius P. A. Janssen…·Mario van der Stelt
CellEKT profiles cellular target engagement of kinase inhibitors using chemical proteomics to determine IC50 values across over 300 kinases and validate results with phosphoproteomics and NanoBRET.