RNA-guided transcriptional repression by TIGR-Tas systems
Peiyu Xu, Lü Long, Annie Zhu, Stephanie Kim, Shai Zilberzwige‐Tal, Natalia Quinones‐Olvera, Lilia Evgeniou, Daniel Flam-Shepherd, Rhiannon K. Macrae, Guilhem Faure, Feng Zhang
TIGRFinder annotated 6,685 TIGR arrays; cryo-EM structures show inactive RuvC domains, and E. coli reporter assays show CsTasR and MbTasA repress transcription in a guide-dependent manner.
bioRxiv · Sep 11, 2026 · PreprintMolecular Biology✦ In-depth digest