Author

Steven R. Leonard

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:clustering· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Biljana BrezinaiD· 2 shared Bradley T. HarrisiD· 2 shared Carl A. AndersoniD· 2 shared Charry Queen Caballes· 2 shared Cristina CotobaliD· 2 shared Gareth‐Rhys JonesiD· 2 shared Jasmin OstermayeriD· 2 shared Jason Skelton· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetic & Genomic Medicine

Biljana BrezinaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

Tobi Alegbe, Bradley T. Harris, Laura Fachal, Lucia Ramirez-Navarro, Marcus Tutert, Monika Krzak, Mennatallah Ghouraba, Michelle Strickland, Matiss Ozols, Celeste E Cohen, Saniya Khullar, Eleonora Khabirova, Nikolaos I. Panousis, David Ochoa, Noor Wana, , Carl A. Anderson

The paper maps cell-type-specific eQTLs in IBD patients to identify effector genes and mechanisms linking genetic risk to disease.

medRxiv · Jun 24, 2025 · PreprintGenetic & Genomic Medicine

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease

Lucia Ramirez-Navarro, Gareth‐Rhys Jones, Tobi Alegbe, Bradley T. Harris, Michelle Strickland, Mennatallah Ghouraba, Jasmin Ostermayer, Noor Wana, Xueqi Hu, Jason Skelton, Wendy Garri, Biljana Brezina, Charry Queen Caballes, Steven R. Leonard, Vivek Iyer, , Tim Raine

This study uses single-cell RNA sequencing to analyze immune cell transcriptional profiles in mucosal and circulatory compartments of Crohn's disease patients, revealing tissue-specific inflammation signatures and identifying circulating T cells with mucosal-like features.

medRxiv · Jun 3, 2025 · PreprintGenetic & Genomic Medicine

Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

Carmen Lidia Diaz Soria, Jayhun Lee, Tracy Chong, Avril Coghlan, Alan Tracey, Matthew D. Young, Tallulah S. Andrews, Christopher L. Hall, Bee Ling Ng, Kate A. Rawlinson, Stephen R. Doyle, Steven R. Leonard, Zhigang Lu, Hayley M. Bennett, Gabriel Rinaldi, , Matthew Berriman

This study creates a single-cell RNA sequencing atlas of the early intra-mammalian stage of Schistosoma mansoni, identifying gene expression profiles and validating cell markers.

Nature Communications · Dec 18, 2020Peer-reviewedGenomics