Jason Skelton

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn's Disease Pathogenesis.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

The paper maps cell-type-specific eQTLs in IBD patients to identify effector genes and mechanisms linking genetic risk to disease.

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease

This study uses single-cell RNA sequencing to analyze immune cell transcriptional profiles in mucosal and circulatory compartments of Crohn's disease patients, revealing tissue-specific inflammation signatures and identifying circulating T cells with mucosal-like features.

The sensory shark: high-quality morphological, genomic and transcriptomic data for the small spotted catshark Scyliorhinus canicula reveal the molecular bases of sensory organ evolution in jawed vertebrates

This study integrates genomic, transcriptomic, and morphological data from the small-spotted catshark to uncover molecular mechanisms underlying sensory organ evolution in jawed vertebrates.

scAbsolute: Measuring single-cell ploidy and replication status

scAbsolute measures single-cell ploidy and replication status using single-cell DNA sequencing without prior knowledge of cell cycle phase.

Complete vertebrate mitogenomes reveal widespread gene duplications and repeats

The paper develops a pipeline for mitochondrial genome assembly and identifies errors and novel duplications in reference mitogenomes.

Template switching mechanism drives the tandem amplification of chromosome 20q11.21 in human pluripotent stem cells

The Gene-Rich Genome of the Scallop Pecten maximus

The paper reports the high-quality genome assembly of Pecten maximus, revealing gene duplicates and highlighting Nav1 as a candidate for toxin resistance.