Avril Coghlan

The histone code of love: epigenetics of maturation of gonads in the human blood fluke Schistosoma mansoni

This study analyzes histone modifications, chromatin accessibility, and transcription in Schistosoma mansoni gonads to uncover the histone code governing gene expression and reproductive development.

Daily rhythms in the transcriptomes of the human parasite Schistosoma mansoni

This study identifies daily transcriptomic rhythms in Schistosoma mansoni, revealing rhythmic gene expression patterns and their potential relevance to parasite survival and drug targets.

Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

This study creates a single-cell RNA sequencing atlas of the early intra-mammalian stage of Schistosoma mansoni, identifying gene expression profiles and validating cell markers.

Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni

This study uses CRISPR-Cas9 to induce deletions in the SULT-OR gene of Schistosoma mansoni, showing potential for oxamniquine resistance but limited mRNA knockdown due to low mutation frequency.

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

This paper demonstrates CRISPR/Cas9-based genome editing in Schistosoma mansoni, successfully mutating the omega-1 gene and reducing Th2 cytokine responses and granuloma formation.

Comparative genomics of the major parasitic worms

This paper compares genomes of 81 nematode and platyhelminth species to identify gene families related to parasitism and prioritize new drug targets.