Author

Susannah K. Leese

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Albert KoulmaniD· 2 shared Andrew M. JamesiD· 2 shared Benjamin JenkinsiD· 2 shared Chak Shun YuiD· 2 shared Clarissa D. Booth· 2 shared Denis LacabanneiD· 2 shared Edmund R.S. KunjiiD· 2 shared Jill M. WeimeriD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Albert KoulmanORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

CLN6 is a glycerophosphoglycerol epimerase in bis(monoacylglycero)phosphate biosynthesis

Pradeep Kumar Sheokand, Andrew M. James, Christian Posern, Amit Singh, Johannes Breithofer, Joe Ganellin, McKayla K. Proulx, Susannah K. Leese, Keira Turner, Denis Lacabanne, Dominik Bulfon, Benjamin Jenkins, Joris van der Kleij, Harvey E. Johnston, Samuel O. Lord, , Kasparas Petkevicius

This study identifies CLN6 as a glycerophosphoglycerol epimerase essential for BMP biosynthesis, showing its deficiency disrupts lysosomal hydrolase homeostasis and can be reversed by BMP precursor supplementation.

bioRxiv · Oct 9, 2026 · PreprintBiochemistry

Stereospecific GPG acylation by CLN8 drives BMP biosynthesis and its loss leads to Batten disease

Pradeep Kumar Sheokand, Denis Lacabanne, Andrew M. James, Stefania Della Vecchia, Jonathan J. Ruprecht, Joris van der Kleij, Keira Turner, Jessica Müller-Niva, Antti M. Salo, Benjamin Jenkins, Susannah K. Leese, Nidhi Juneja, Chak Shun Yu, Clarissa D. Booth, Martin S. King, , Kasparas Petkevicius

This study identifies CLN8 as a stereospecific GPG acyltransferase critical for BMP biosynthesis, showing its loss causes Batten disease and that S,S-LPG supplementation can restore BMP and improve neurological symptoms.

Nature Cell Biology · Sep 15, 2026Peer-reviewedBiochemistry