Author

Sveta Gaiduk

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:protein design· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Ariel TennenhouseiD· 2 shared Sarel Jacob FleishmaniD· 2 shared Adva MechalyiD· 1 shared Andrew B Dippel· 1 shared Christopher Domalewski· 1 shared Daniel ChristiD· 1 shared Dorry X Zhao· 1 shared Eliane Hadas YardeniiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Ariel TennenhouseORCID

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2 papers

Recent·Most cited

Computational design of structurally diverse antibody repertoires with drug-like properties

Ariel Tennenhouse, Rebecca E Wilen, Sveta Gaiduk, Roman Kamyshinsky, Sarah Borni, Mazal Faraj, Eliane Hadas Yardeni, Moshe Goldsmith, Inbar Cahana, Shira Albeck, Tamar Unger, Rony Dahan, Ron Diskin, Sarel Jacob Fleishman

The paper designs structurally diverse antibody repertoires with drug-like properties using a computational method called CADAbRe, demonstrating their utility in binding to challenging targets.

bioRxiv · Jul 13, 2026 · PreprintSynthetic Biology

Energy-guided combinatorial co-optimization of antibody affinity and stability

Ariel Tennenhouse, Adva Mechaly, Tony Pham, Robert J. Oldham, Jake Y. Henry, Dorry X Zhao, Thomas M Moon, Isabel G Elliott, Omri Porat, Jinny Kim, Yael Fridmann Sirkis, Sveta Gaiduk, Itay Talpir, Jamie Bird, Christopher Domalewski, , Sarel Jacob Fleishman

This paper introduces LAffAb, a method to co-optimize antibody affinity and stability through combinatorial mutation design, achieving significant affinity gains while maintaining developability.

bioRxiv · Nov 26, 2025 · PreprintSynthetic Biology