Roman A. Kamyshinsky

Computational design of structurally diverse antibody repertoires with drug-like properties

The paper designs structurally diverse antibody repertoires with drug-like properties using a computational method called CADAbRe, demonstrating their utility in binding to challenging targets.

Extracellular Vesicles Mediate Glucose Regulation by GLUT4-Overexpressing Engineered Muscle Tissue in T2D Mice

This study shows that extracellular vesicles from GLUT4-overexpressing engineered muscle tissue improve glucose uptake and insulin sensitivity in T2D mice.

A multiplexed approach for genetic screening of human cells by electron microscopy uncovers a critical effector of mitochondrial cristae shape

The paper develops hMultiCLEM, a high-resolution screening pipeline combining EM and multiplexed human cell pools to identify proteins affecting mitochondrial cristae shape, uncovering MISHA linked to Meniere's disease.

Oligomeric hypercomplex of the complete oxidative phosphorylation system in heart mitochondria.

This study uses cryo-electron tomography to reveal the supramolecular architecture of the oligomeric hypercomplex in rat heart mitochondria, showing direct proton transfer between respiratory chain supercomplexes and ATP synthases.