Efficient Genome Editing with Chimeric Oligonucleotide-Directed Editing
Long Thành Nguyễn, Noah R. Rakestraw, Brianna L.M. Pizzano, Rajan Iyyappan, Cullen B. Young, Yujia Huang, Kate T Beerensson, Anne Fang, Sydney G Antal, Katerina V Anamisis, Coleen Michelle Deans Peggs, Jun Yan, Yangwode Jing, Jordan G. Lewis, Rebecca D. Burdine, , Piyush Jain
This paper introduces CODEMax and CODEMax(exo+) genome editing systems that enable efficient and precise search-and-replace editing in human cells with reduced off-target effects.
Nature Communications · Apr 13, 2026Peer-reviewedBioengineering