Author

Sylvain W. Lapan

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Organism:Drosophila· 1 Organism:human· 1 Organism:plant (other)· 1

Frequent Co-Authors

Constance L. CepkoiD· 3 shared Emma R. WestiD· 3 shared Akshada B. Redkar· 1 shared Allen Zhu· 1 shared Brian J. BeliveauiD· 1 shared ChangHee Lee· 1 shared Elizabeth A. LaneiD· 1 shared Hiroshi M. SasakiiD· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersDevelopmental Biology

Constance L. CepkoORCID

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Author profile →

4 papers

Recent·Most cited

Krüppel-like factor 4 is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians

Melanie Issigonis, Akshada B. Redkar, Tania Rozario, Umair W. Khan, Rosa Mejia-Sanchez, Sylvain W. Lapan, Peter W. Reddien, Phillip A. Newmark

This study shows that Klf4 is essential for germline and yolk cell development and regeneration from somatic stem cells in planarians.

PLoS Biology · Jul 15, 2022Peer-reviewedDevelopmental Biology

Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity

Emma R. West, Sylvain W. Lapan, ChangHee Lee, Kathrin M Kajderowicz, Xihao Li, Constance L. Cepko

The paper maps the spatiotemporal development of bipolar interneuron subtypes in the mammalian retina, revealing a hierarchical model of subtype genesis through ordered birthdates and oscillatory waves.

Cell Reports · Jan 1, 2022Peer-reviewedDevelopmental Biology

Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation

Ryoji Amamoto, M Garcia, Emma R. West, Jiho Choi, Sylvain W. Lapan, Elizabeth A. Lane, Norbert Perrimon, Constance L. Cepko

Probe-Seq isolates and profiles specific cell types from heterogeneous tissues using RNA-based fluorescence sorting, applicable across multiple organisms.

eLife · Dec 9, 2019Peer-reviewedMolecular Biology

SABER enables highly multiplexed and amplified detection of DNA and RNA in cells and tissues

Jocelyn Y. Kishi, Sylvain W. Lapan, Brian J. Beliveau, Emma R. West, Allen Zhu, Hiroshi M. Sasaki, Sinem K. Saka, Yu Wang, Constance L. Cepko, Peng Yin

SABER enables highly multiplexed and amplified detection of DNA and RNA in cells and tissues by using oligo-based probes with long DNA concatemers for sensitive fluorescent detection.

Nature Methods · May 20, 2019Peer-reviewedGenetics