Author

C. E. Coupland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Siebold· 4 shared T. B. Ansell· 3 shared A. I. Magee· 2 shared E. W. Tate· 2 shared L. Carrique· 2 shared L. Sefer· 2 shared M. S. P. Sansom· 2 shared S. A. Andrei· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersBiochemistry

C. Siebold

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Author profile →

5 papers

Recent·Most cited

High resolution cryo-EM of V-ATPase in native synaptic vesicles

C. E. Coupland, R. Karimi, S. A. Bueler, Y. Liang, G. M. Courbon, J. M. Di Trani, C. J. Wong, R. Saghian, J.-Y. Youn, L.-Y. Wang, J. L. Rubinstein

The paper determines the high-resolution structure of V-ATPase in native synaptic vesicles using cryo-EM, revealing interactions with cholesterol and synaptophysin.

bioRxiv · Apr 1, 2024Biochemistry

Mapping Structural and Dynamic Divergence Across the MBOAT family

T. B. Ansell, M. Healy, C. E. Coupland, M. S. P. Sansom, C. Siebold

This study uses molecular dynamics and bioinformatics to analyze structural and dynamic differences across MBOAT family members, identifying key features relevant to inhibitor design.

bioRxiv · Dec 18, 2023Biochemistry

LipIDens: Simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.

T. B. Ansell, W. Song, C. E. Coupland, L. Carrique, R. A. Corey, A. L. Duncan, C. K. Cassidy, M. M. G. Guerts, T. Rasmussen, A. B. Ward, C. Siebold, P. J. Stansfeld, M. Sansom

LipIDens uses MD simulations to interpret lipid-like densities in cryo-EM maps of membrane proteins, revealing protein-lipid interactions.

bioRxiv · Jun 30, 2022Biophysics

Structure and Mechanism of Hedgehog Acyl Transferase

C. E. Coupland, S. A. Andrei, T. B. Ansell, L. Carrique, P. Kumar, L. Sefer, R. A. Schwab, E. F. X. Byrne, E. Pardon, J. Steyaert, A. I. Magee, M. S. P. Sansom, E. W. Tate, C. Siebold

The paper presents the cryo-EM structure of HHAT, revealing its mechanism for transferring palmitate to SHH and identifying a heme group essential for its function.

bioRxiv · Jul 8, 2021 · PreprintBiophysics

Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase

T. Lanyon-Hogg, M. Ritzefeld, L. Zhang, B. Pogranyi, M. Mondal, C. D. Johnston, C. E. Coupland, L. Sefer, S. A. Andrei, J. Newington, A. I. Magee, C. Siebold, E. W. Tate

This study develops a photochemical probe to identify the small-molecule binding site in HHAT, leading to the discovery of a potent inhibitor and insights into MBOAT inhibition mechanisms.

bioRxiv · Oct 16, 2020 · PreprintBiochemistry