Author

M. Healy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

B. Collins· 2 shared J. Sacharz· 2 shared K.-E. Chen· 2 shared R. Ghai· 2 shared A. Bademosi· 1 shared A. Jiang· 1 shared A. K. Kendall· 1 shared A. Malapaka· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

B. Collins

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4 papers

Recent·Most cited

Mapping Structural and Dynamic Divergence Across the MBOAT family

T. B. Ansell, M. Healy, C. E. Coupland, M. S. P. Sansom, C. Siebold

This study uses molecular dynamics and bioinformatics to analyze structural and dynamic differences across MBOAT family members, identifying key features relevant to inhibitor design.

bioRxiv · Dec 18, 2023Biochemistry

Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2

S. Weeratunga, R. Gormal, M. Liu, D. Eldershaw, E. Livingstone, A. Malapaka, T. Wallis, A. Bademosi, A. Jiang, M. Healy, F. Meunier, B. Collins

The paper uses AlphaFold2 to identify and validate interactions of Mint proteins with Munc18-1 and their broader interactome, revealing structural and functional insights into neuronal membrane trafficking.

bioRxiv · Feb 20, 2023Biochemistry

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

M. Healy, K. McNally, R. Butkovic, M. Chilton, K. Kato, J. Sacharz, C. McConville, E. Moody, S. Shaw, V. Planelles-Herrero, S. Yadav, J. Ross, U. Borucu, C. Palmer, K.-E. Chen, , P. Cullen

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

bioRxiv · Jan 25, 2023 · PreprintBiochemistry

De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

K.-E. Chen, Q. Guo, T. A. Hill, Y. Cui, A. K. Kendall, Z. Yang, R. J. Hall, M. Healy, J. Sacharz, S. J. Norwood, S. Fonseka, B. Xie, R. C. Reid, N. Leneva, R. G. Parton, , B. M. Collins

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

bioRxiv · Dec 3, 2020 · PreprintBiochemistry