Author

S. C. Letham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Organism:E. coli· 1

Frequent Co-Authors

P. J. Stansfeld· 2 shared A. K. Tarafder· 1 shared C. Siebold· 1 shared G. R. Young· 1 shared I. A. Taylor· 1 shared J. Boehning· 1 shared J. P. Stoye· 1 shared L. Curran· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

P. J. Stansfeld

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biophysical basis of phage liquid crystalline droplet-mediated antibiotic tolerance in pathogenic bacteria

J. Boehning, M. Graham, S. C. Letham, L. K. Davis, U. Schulze, P. J. Stansfeld, R. A. J. Corey, P. Pearce, A. K. Tarafder, T. A. M. Bharat

This study investigates liquid crystalline droplets formed by inoviral phages in bacteria, showing they protect cells from antibiotics through biophysical properties rather than surface chemistry.

bioRxiv · Dec 13, 2022 · PreprintMicrobiology

Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

T. B. Ansell, L. Curran, M. R. Horrell, T. Pipatpolkai, S. C. Letham, W. Song, C. Siebold, P. J. Stansfeld, M. S. P. Sansom, R. A. Corey

This study develops a method to determine protein-lipid binding affinities from MD simulations and validates it against experimental and computational methods.

bioRxiv · Jun 2, 2021Biophysics

Structure of D. melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

M. A. Cottee, S. C. Letham, G. R. Young, J. P. Stoye, I. A. Taylor

The paper presents the crystal structure of dARC1 and compares it to mammalian ARC and retroviral CA proteins, showing structural divergence and functional adaptation.

bioRxiv · Jul 10, 2019Evolutionary Biology