Author

J. C. M. Gebhardt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Cell Biology· 2 Cancer Biology· 1

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Research Focus:chromatin & epigenetic regulation· 6 Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Assay:fluorescence / live-cell microscopy· 4 Assay:imaging· 3 Approach:microscopy & imaging analysis· 3 Approach:statistical model· 3

Frequent Co-Authors

T. Kuhn· 6 shared J. Hettich· 4 shared A. Grosse-Berkenbusch· 2 shared A. W. Cook· 2 shared J. Cossmann· 2 shared L. Streit· 2 shared N. Fili· 2 shared T. Vomhof· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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6 shared papersBiophysics

T. Kuhn

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Author profile →

10 papers

Recent·Most cited

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

D. Huynh, P. Hoffmeister, T. Friedrich, K. Zhang, M. Bartkuhn, F. Ferrante, B. D. Giaimo, R. Kovall, T. Borggrefe, F. Oswald, J. C. M. Gebhardt

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

bioRxiv · Dec 19, 2023Biophysics

Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis

J. Cossmann, P. I. Kos, V. Varamogianni-Mamatsi, D. Assenheimer, T. Bischof, T. Kuhn, T. Vomhof, A. Papantonis, L. Giorgetti, J. C. M. Gebhardt

The paper investigates cohesin and CTCF chromatin binding dynamics during zebrafish embryogenesis, showing increased binding efficiency and its role in chromatin architecture formation.

bioRxiv · Dec 8, 2023Biophysics

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

N. Schleussner, P. Cauchy, V. Franke, M. Giefing, O. Fornes, N. Vankadari, S. Assi, M. Costanza, M. A. Weniger, A. Akalin, I. Anagnostopoulos, T. Bukur, M. G. Casarotto, F. Damm, O. Daumke, , R. Grosschedl

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

bioRxiv · Dec 29, 2022 · PreprintCancer Biology

Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model

T. Kuhn, A. N. Landge, D. Moersdorf, J. Cossmann, J. Gerstenecker, P. Mueller, J. C. M. Gebhardt

The paper uses single-molecule tracking to support the hindered diffusion model in zebrafish embryos by analyzing Nodal and Lefty diffusion dynamics.

bioRxiv · Apr 5, 2022Biophysics

Stress induced TDP-43 mobility loss independent of stress granules

L. Streit, T. Kuhn, T. Vomhof, A. C. Ludolph, J. H. Weishaupt, J. C. M. Gebhardt, J. Michaelis, K. M. Danzer

The paper investigates TDP-43 mobility under stress and recovery, finding stress-induced mobility loss in cytoplasm and nucleus, independent of stress granules.

bioRxiv · Feb 28, 2022Biophysics

Transcription factor residence time dominates over concentration in transcription activation

A. P. Popp, J. Hettich, J. C. M. Gebhardt

The paper investigates how transcription factor residence time affects transcriptional burst frequency and develops a model of gene transcription based on quantitative measurements.

bioRxiv · Nov 26, 2020 · PreprintBiophysics

Single molecule tracking and analysis framework including theory-predicted parameter settings

T. Kuhn, J. Hettich, J. C. M. Gebhardt

The paper introduces TrackIt, a framework for single molecule tracking and analysis that addresses tracking errors and provides optimized parameters for reliable quantification of molecular dynamics.

bioRxiv · Nov 25, 2020Biophysics

Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.

Y. Hari-Gupta, N. Fili, A. dos Santos, A. W. Cook, R. E. Gough, H. C. W. Reed, L. Wang, J. Arron, T. Venit, E. Waite, A. Grosse-Berkenbusch, J. C. M. Gebhardt, P. Percipalle, T. L. Chew, M. L. Martin-Fernandez, C. P. Toseland

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

bioRxiv · Apr 21, 2020Cell Biology

Myosin VI moves on nuclear actin filaments and supports long-range chromatin rearrangements

A. Grosse-Berkenbusch, J. Hettich, T. Kuhn, N. Fili, A. W. Cook, Y. Hari-Gupta, A. Palmer, L. Streit, P. J. I. Ellis, C. Toseland, J. C. M. Gebhardt

This study shows nuclear myosin VI moves along actin filaments and facilitates transcription-dependent chromatin rearrangements.

bioRxiv · Apr 3, 2020 · PreprintCell Biology

Inferring quantity and qualities of superimposed reaction rates in single molecule survival time distributions

M. Reisser, J. Hettich, T. Kuhn, J. C. M. Gebhardt

This paper introduces GRID, a method to infer dissociation rates and frequencies from single molecule survival time distributions, and applies it to study CDX2 dissociation from chromatin.

bioRxiv · Jun 21, 2019Biophysics