I. Forne

The role of RNA in the maintenance of chromatin domains as revealed by antibody mediated proximity labelling coupled to mass spectrometry

The paper introduces AMPL-MS to study chromatin domains in Drosophila, showing RNA's role in maintaining their proteomic composition.

Decrypting the functional design of unmodified translation elongation factor P

This study identifies unmodified EF-P variants from Rhodomicrobium vannielii that restore function in E. coli lacking EF-P modifications, revealing design principles for polyproline synthesis.

Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells

The paper develops a peptide inhibitor targeting the Elongin BC dimer, showing reduced cancer cell viability and increased apoptosis by blocking its interaction partners.

A central protein complex essential for Invasionin Toxoplasma gondii

The paper identifies a central protein complex in Toxoplasma gondii essential for invasion, showing that disruption of this complex blocks rhoptry secretion and host cell invasion.

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation in Drosophila

This study identifies a six-subunit Speciation Core Complex containing Hmr and Lhr, showing Hmr's role in centromeric binding and hybrid male lethality in Drosophila.

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

Dietary intervention improves health metrics and life expectancy of the genetically obese DU6 (Titan) mouse

The study characterizes the Titan mouse as a model for metabolically unhealthy obesity and shows that dietary intervention improves its health and extends lifespan.

Helicobacter hepaticus as disease driver in a novel CD40-mediated model of colitis

This study identifies Helicobacter hepaticus as a disease driver in a CD40-mediated colitis model by showing its role in inducing inflammatory immune responses through specific antigen recognition.