Author

T. G. Shepherd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. O. Cudmore· 1 shared A. Tone· 1 shared B. C. Vanderhyden· 1 shared B. L. Worley· 1 shared C.-W. Chen· 1 shared D. P. Cook· 1 shared D.-H. Shin· 1 shared E. MacDonald· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. O. Cudmore

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2 papers

Recent·Most cited

Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer

D. P. Cook, K. J. Galpin, G. M. Rodriguez, N. Shakfa, J. Wilson-Sanchez, M. Pereira, K. Matuszewska, J. Haagsma, H. Murshed, A. O. Cudmore, E. MacDonald, A. Tone, T. G. Shepherd, J. J. Petrik, M. Koti, B. C. Vanderhyden

The paper compares syngeneic mouse models of high-grade serous ovarian cancer to identify differences in signaling, metabolic, and functional properties, as well as tumor microenvironment variability.

bioRxiv · Mar 9, 2023Cancer Biology

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

Y. S. Kim, P. Gupta-Vallur, V. M. Jones, B. L. Worley, S. Shimko, D.-H. Shin, L. C. Crawford, C.-W. Chen, K. M. Aird, T. Abraham, T. G. Shepherd, J. I. Warrick, N. Y. Lee, R. Phaeton, K. Mythreye, N. Hempel

This study shows that SIRT3 activation is required for ovarian cancer cell survival and metastasis by regulating mitochondrial antioxidant defenses and metabolic changes during detachment.

bioRxiv · Jun 13, 2019Cancer Biology