Author

J. I. Warrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. J. DeGraff· 3 shared C.-W. Chen· 2 shared K. M. Aird· 2 shared V. Walter· 2 shared B. L. Worley· 1 shared D.-H. Shin· 1 shared E. S. Dahl· 1 shared G. B. Mills· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

D. J. DeGraff

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4 papers

Recent·Most cited

Urothelium-specific expression of mutationally activated Pik3ca initiates early lesions of non-invasive bladder cancer

L. Shuman, J. Pham, T. Wildermuth, X.-R. Wu, V. Walter, J. I. Warrick, D. J. DeGraff

This study creates a mouse model to study PIK3CA mutations in bladder cancer, showing early tumorigenic changes but no progression to invasion without additional genetic factors.

bioRxiv · May 22, 2023 · PreprintCancer Biology

Loss of the Pioneer Factor FOXA1 Results in Genome-wide Epigenetic Reprogramming and activation of Interferon-Response Genes including CD274/PD-L1

W. Hu, H. Yamashita, J. Craig, V. Walter, J. I. Warrick, H. Al-Ahmadie, D. J. DeGraff

This study shows that FOXA1 loss in bladder cancer causes widespread epigenetic changes and activates interferon-response genes like PD-L1.

bioRxiv · Sep 11, 2020 · PreprintCancer Biology

Suppression of p16 increases nucleotide synthesis via mTORC1

R. Buj, C.-W. Chen, E. S. Dahl, K. E. Leon, R. Kuskovsky, N. Maglakelidze, M. Navaratnarajah, G. Zhang, M. T. Doan, H. Jiang, M. Zaleski, L. Kutzler, H. Lacko, Y. Lu, G. B. Mills, , K. M. Aird

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

bioRxiv · Jul 20, 2019Cancer Biology

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

Y. S. Kim, P. Gupta-Vallur, V. M. Jones, B. L. Worley, S. Shimko, D.-H. Shin, L. C. Crawford, C.-W. Chen, K. M. Aird, T. Abraham, T. G. Shepherd, J. I. Warrick, N. Y. Lee, R. Phaeton, K. Mythreye, N. Hempel

This study shows that SIRT3 activation is required for ovarian cancer cell survival and metastasis by regulating mitochondrial antioxidant defenses and metabolic changes during detachment.

bioRxiv · Jun 13, 2019Cancer Biology