Author

B. C. Vanderhyden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 3

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Research Focus:cell type annotation· 6 Organism:mouse· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

D. P. Cook· 6 shared A. N. Karnezis· 1 shared A. O. Cudmore· 1 shared A. Sekulic· 1 shared A. Tone· 1 shared A. Vadivel· 1 shared B. E. Weissman· 1 shared B. Thebaud· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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6 shared papersCancer Biology

D. P. Cook

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer

D. P. Cook, K. J. Galpin, G. M. Rodriguez, N. Shakfa, J. Wilson-Sanchez, M. Pereira, K. Matuszewska, J. Haagsma, H. Murshed, A. O. Cudmore, E. MacDonald, A. Tone, T. G. Shepherd, J. J. Petrik, M. Koti, B. C. Vanderhyden

The paper compares syngeneic mouse models of high-grade serous ovarian cancer to identify differences in signaling, metabolic, and functional properties, as well as tumor microenvironment variability.

bioRxiv · Mar 9, 2023Cancer Biology

Single-cell RNA sequencing-based characterization of resident lung mesenchymal stromal cells in bronchopulmonary dysplasia

I. Mizikova, F. Lesage, C. Cyr-Depauw, D. P. Cook, M. Hurskainen, S. Hanninen, A. Vadivel, P. Bardin, S. Zhong, O. Carpen, B. C. Vanderhyden, B. Thebaud

This study uses scRNA-seq to characterize resident lung mesenchymal stromal cells in normal development and BPD, finding hyperoxia alters their gene expression and identifies Serpinf1 as a stable marker.

bioRxiv · Jun 18, 2021Cell Biology

Transcriptional census of epithelial-mesenchymal plasticity in cancer

D. P. Cook, B. C. Vanderhyden

The paper identifies expression patterns of epithelial-mesenchymal plasticity in 160 tumors across 8 cancer types using scRNA-seq and links these patterns to regulatory mechanisms in the tumor microenvironment.

bioRxiv · Mar 5, 2021Cancer Biology

Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

L. E. Carter, D. P. Cook, C. W. McCloskey, T. Dang, O. Collins, L. F. Gamwell, H. A. Dempster, B. C. Vanderhyden

This study investigates stemness traits in ovarian surface epithelium and finds that stemness is context-specific and not consistently linked to specific signaling pathways or a single population.

bioRxiv · Jun 10, 2020Cell Biology

Cre-mediated deletion of SMARCA5 disrupts pluripotency in mouse embryonic stem cells

D. P. Cook, B. C. Vanderhyden

This study shows that deleting Snf2h in mouse ESCs disrupts pluripotency by altering key markers and genome-wide nucleosome distribution.

bioRxiv · Apr 2, 2020 · PreprintCell Biology

Comparing transcriptional dynamics of the epithelial-mesenchymal transition

D. P. Cook, B. C. Vanderhyden

This study compares the transcriptional dynamics of the epithelial-mesenchymal transition across multiple contexts, identifying conserved genes and transcription factors involved in the process.

bioRxiv · Aug 13, 2019Cancer Biology

Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

J. D. Lang, W. P. D. Hendricks, H. Yin, J. Kiefer, P. Ramos, R. Sharma, P. Pirrotte, E. A. Raupach, C. Sereduk, N. Tang, W. S. Liang, M. Washington, S. J. Facista, V. L. Zismann, E. M. Cousins, , J. M. Trent

This paper identifies ponatinib as a potent treatment for SCCOHT by inhibiting multiple kinases in preclinical models.

bioRxiv · Jul 6, 2017Cancer Biology