T. Ganguly

The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and Their Relationship to Oncogenic Drivers

This study identifies imaging and spatial biomarkers in glioblastoma that correlate with molecular features and oncogenic drivers using machine learning on MRI data.

Post-translational modification by the Pgf glycosylation machinery modulates Streptococcus mutans physiology and virulence

This study shows that the Pgf glycosylation machinery in Streptococcus mutans modifies surface proteins, affecting biofilm formation and virulence, with phosphorylation compensating for glycosylation loss.

ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication

This study identifies ZccE, a P-type ATPase in Streptococcus mutans, as a key factor in its high zinc tolerance and resistance to multiple metal ions, offering a potential target for antimicrobial therapies.

Amyloid aggregation of Streptococcus mutans Cnm influences its collagen-binding activity

This study shows that Cnm, a collagen-binding protein in S. mutans, forms amyloids that lose collagen-binding activity, modulating biofilm function.

Zinc Import Mediated by AdcABC is Critical for Colonization of the Dental Biofilm by Streptococcus mutans in an Animal Model

This study identifies AdcABC as the sole high-affinity zinc importer in S. mutans and shows its critical role in biofilm colonization and survival under zinc-depleted conditions.

Increased oxidative stress tolerance of a spontaneously-occurring perR gene mutation in Streptococcus mutans UA159

The paper identifies a perR gene mutation in S. mutans UA159 that increases oxidative stress tolerance, but shows minimal transcriptional impact, highlighting the need for strain authentication.

Manganese uptake, mediated by SloABC and MntH, is essential for the fitness of Streptococcus mutans

This study shows that manganese uptake via SloABC and MntH is critical for Streptococcus mutans growth and virulence under manganese restriction.