Author

J. A. Lemos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 12

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:host-pathogen & immune response· 10 Research Focus:cell type annotation· 3 Organism:E. coli· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

J. Abranches· 6 shared J. K. Kajfasz· 6 shared T. Ganguly· 6 shared A. L. Flores-Mireles· 3 shared C. Colomer-Winter· 3 shared L. N. Lam· 3 shared A. M. Peterson· 2 shared J. A. Vargas· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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6 shared papersMicrobiology

J. Abranches

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence

J. A. Lemos, D. N. Brunson, L. N. Lam, C. Colomer-Winter

This study identifies five iron uptake systems in Enterococcus faecalis and shows their collective role in virulence and iron homeostasis, with heme utilization critical for systemic infection.

bioRxiv · Nov 4, 2022 · PreprintMicrobiology

Post-translational modification by the Pgf glycosylation machinery modulates Streptococcus mutans physiology and virulence

N. de Mojana di Cologna, S. Andresen, S. Samaddar, S. A. Archer-Hartmann, T. Ganguly, J. K. Kajfasz, B. A. Garcia, I. Saengpet, A. M. Peterson, P. Azadi, C. M. Szymanski, J. A. Lemos, J. A. Abranches

This study shows that the Pgf glycosylation machinery in Streptococcus mutans modifies surface proteins, affecting biofilm formation and virulence, with phosphorylation compensating for glycosylation loss.

bioRxiv · Oct 10, 2022 · PreprintMicrobiology

ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication

T. Ganguly, A. Peterson, M. Burkholder, J. K. Kajfasz, J. Abranches, J. A. Lemos

This study identifies ZccE, a P-type ATPase in Streptococcus mutans, as a key factor in its high zinc tolerance and resistance to multiple metal ions, offering a potential target for antimicrobial therapies.

bioRxiv · Mar 29, 2022Microbiology

Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in polymicrobial biofilms

C. A. Z. Tan, L. N. Lam, G. Biukovic, E. Y.-C. Soh, X. W. Toh, J. A. Lemos, K. A. Kline

This study shows that Enterococcus faecalis inhibits Pseudomonas aeruginosa growth in iron-restricted biofilms through lactic acid production and pH reduction.

bioRxiv · Jan 18, 2022 · PreprintMicrobiology

The AdcACB/AdcAII system is Essential for Zinc Homeostasis and an Important Contributor of Enterococcus faecalis Virulence

J. A. Lemos, L. Lam, D. Brunson, A. L. Flores-Mireles, J. J. Molina

bioRxiv · Dec 1, 2021Microbiology

Amyloid aggregation of Streptococcus mutans Cnm influences its collagen-binding activity

N. de Mojana di Cologna, S. Samaddar, C. Valle, J. A. Vargas, A. Aviles-Reyes, J. Morales, T. Ganguly, R. Pileggi, L. J. Brady, J. A. Lemos, J. Abranches

This study shows that Cnm, a collagen-binding protein in S. mutans, forms amyloids that lose collagen-binding activity, modulating biofilm function.

bioRxiv · Jun 9, 2021Microbiology

c-di-AMP is essential for the virulence of Enterococcus faecalis

S. Kundra, L. N. Lam, J. K. Kajfasz, L. Casella, M. J. Andersen, J. Abranches, A. Flores-Mireles, J. A. Lemos

This study shows that c-di-AMP is essential for the virulence of Enterococcus faecalis, as its absence or accumulation impairs cell fitness and pathogenicity in multiple models.

bioRxiv · May 19, 2021Microbiology

Zinc Import Mediated by AdcABC is Critical for Colonization of the Dental Biofilm by Streptococcus mutans in an Animal Model

T. Ganguly, A. M. Peterson, J. K. Kajfasz, J. Abranches, J. A. Lemos

This study identifies AdcABC as the sole high-affinity zinc importer in S. mutans and shows its critical role in biofilm colonization and survival under zinc-depleted conditions.

bioRxiv · Jan 22, 2021Microbiology

Increased oxidative stress tolerance of a spontaneously-occurring perR gene mutation in Streptococcus mutans UA159

J. K. Kajfasz, P. Zuber, T. Ganguly, J. Abranches, J. A. Lemos

The paper identifies a perR gene mutation in S. mutans UA159 that increases oxidative stress tolerance, but shows minimal transcriptional impact, highlighting the need for strain authentication.

bioRxiv · Sep 24, 2020Microbiology

Manganese uptake, mediated by SloABC and MntH, is essential for the fitness of Streptococcus mutans

J. A. Lemos, J. K. Kajfasz, T. Ganguly, G. A. Spatafora, J. Abranches, C. Katrak, J. A. Vargas, L. T. Wright, Z. T. Peters

This study shows that manganese uptake via SloABC and MntH is critical for Streptococcus mutans growth and virulence under manganese restriction.

bioRxiv · Oct 24, 2019Microbiology

(p)ppGpp and CodY promote Enterococcus faecalis virulence in a murine model of catheter-associated urinary tract infection

C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos

This study shows that (p)ppGpp and CodY enhance Enterococcus faecalis virulence in a mouse model of catheter-associated urinary tract infection by maintaining metabolic balance during infection.

bioRxiv · May 31, 2019Microbiology

Manganese acquisition is essential for virulence of Enterococcus faecalis

C. Colomer-Winter, A. L. Flores-Mireles, S. P. Baker, K. L. Frank, A. J. Lynch, S. J. Hultgren, T. Kitten, J. A. Lemos

This study identifies and characterizes Mn acquisition systems in E. faecalis, showing their critical role in virulence and demonstrating their potential as antimicrobial targets.

bioRxiv · May 16, 2018Microbiology