T. Hart

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19

The paper characterizes the CAST/EiJ mouse strain as a model for severe COVID-19 by showing it develops high viral burdens, severe lung pathology, and cytokine dysregulation leading to mortality.

Unselfish meiotic drive maintains heterozygosity in a parthenogenetic ant

The paper shows that unselfish meiotic drive prevents loss of heterozygosity in the clonal raider ant by ensuring crossover products are co-inherited.

A general deep learning model for bird detection in high resolution airborne imagery

The paper develops a general deep learning model for bird detection in aerial imagery, achieving high recall and precision with minimal local training.

Imprinting on time-structured acoustic stimuli in ducklings

This study shows that day-old Mallard ducklings imprint on the temporal structure of acoustic stimuli and generalize this timing information to novel sounds when imprinted with natural calls.

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

Environmental DNA facilitates accurate, indigenous-led, inexpensive, and multi-year population estimates of millions of Eulachon fish

This study shows that environmental DNA (eDNA) can accurately estimate eulachon fish populations over multiple years, with high predictive power compared to mark-recapture methods, at a lower cost.

Mobility in Osteogenesis Imperfecta: A Multicenter North American Study

This study characterizes mobility in osteogenesis imperfecta using clinical data from 491 individuals, finding height and weight as key predictors and varying effects of bisphosphonates by OI type.