W. Yao

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

AI in Paleontology

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

Isolation and nitrogen removal characteristics of a novel aerobic denitrifying strain Achromobacter xylosoxidans GR7397

This study isolates a novel aerobic denitrifying strain, Achromobacter xylosoxidans GR7397, and demonstrates its efficient nitrate removal capacity under optimized conditions.

Broadly effective ACE2 decoy proteins protect mice from lethal SARS-CoV-2 infection

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.

Genetic Diversity of Candidatus Liberibacter asiaticus Based on Four Hypervariable Genomic Regions in China

This study analyzes genetic diversity of Candidatus Liberibacter asiaticus in China using hypervariable genomic regions to understand strain differences and inform HLB control strategies.

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

A dual reporter system identifies an intermediate state and sequential regulators of 2-cell-like-to-pluripotent state transition

The paper identifies an intermediate state during 2C-like-to-pluripotent state transition using a dual reporter system and finds key regulators involved in this process.

A trimeric NTD and RBD SARS-CoV-2 subunit vaccine induced protective immunity in CAG-hACE2 transgenic mice and rhesus macaques

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

Effect of SARS-CoV-2 spike mutations on animal ACE2 usage and in vitro neutralization sensitivity

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

A new method for distinguishing human and mouse cells in situ

This paper introduces a method using DAPI staining to distinguish human and mouse cells in situ, showing distinct nuclear structures in mouse cells.

Forkhead box O1-mediated ubiquitination suppresses RIG-I-mediated antiviral immune responses via its DNA binding domain

The paper withdraws its manuscript due to the need for further experiments to validate conclusions.

YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

Overview of the SAMPL6 host-guest binding affinity prediction challenge

This paper provides an overview of the SAMPL6 host-guest binding affinity prediction challenge, highlighting methodological improvements and remaining challenges in predicting binding affinities.