Author

T. Hiratsuka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

F. M. Watt· 2 shared A. Ueda· 1 shared E. Miyoshi· 1 shared E. Rognoni· 1 shared G. Goss· 1 shared G. Pruessner· 1 shared H. H. Freeze· 1 shared H. Tahara· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

F. M. Watt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

Y. Harada, Y. Mizote, T. Suzuki, M. Nishida, T. Hiratsuka, A. Ueda, Y. Imagawa, K. Maeda, Y. Ohkawa, J. Murai, H. H. Freeze, E. Miyoshi, S. Higashiyama, H. Udono, N. Dohmae, , N. Taniguchi

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

bioRxiv · Oct 17, 2022Cancer Biology

Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage

E. Rognoni, G. Goss, T. Hiratsuka, K. I. Kober, P. P. Lui, V. S. Tsang, N. Hawkshaw, S. M. Pilkington, K. Sipilä, I. Cho, N. Ali, L. E. Rhodes, F. M. Watt

This study investigates the role of fibroblast lineages and immune cells in dermal repair after UV radiation damage, finding that T cells support fibroblast survival and that COX-2 inhibition prevents fibroblast depletion.

bioRxiv · Jun 8, 2021Cell Biology

ERK basal and pulsatile activity are differentially regulated in mammalian epidermis to control proliferation and exit from the stem cell compartment

T. Hiratsuka, I. Bordeu, G. Pruessner, F. M. Watt

The paper shows that ERK activity in mammalian epidermis is regulated by pulsatile and basal dynamics, with DUSP10 and DUSP6 controlling different aspects of differentiation.

bioRxiv · Apr 12, 2020Cell Biology