M. Nishida

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17

This study generates and characterizes monoclonal IgM and IgG antibodies against norovirus variants GII.4 and GII.17, revealing differences in binding mechanisms and affinity.

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

The paper identifies GIF/metallothionein-3 as a sulfane sulfur-binding protein that regulates zinc ion binding and release through a unique C-S-S-Zn structure.

NMR analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria

The paper determines the dimeric structure of VanX using NMR and identifies a monomeric form for inhibitor screening.

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction

This study identifies remdesivir as a selective agonist of the urotensin-II receptor, linking its cardiotoxicity to receptor activation and genetic variants.

Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

The paper shows that glutamine deficiency in cancer cells prevents p53 activation by rRNA synthesis inhibitors, promoting survival during nutrient stress.

A root for massive crown-of-thorns starfish outbreaks in the Pacific Ocean

The paper identifies two mitochondrial clades of crown-of-thorns starfish, showing one clade is associated with outbreaks while the other is not, linking dispersal and environmental factors to outbreak patterns.

Clomipramine suppresses ACE2-mediated SARS-CoV-2 entry

This study shows clomipramine inhibits SARS-CoV-2 entry into cardiomyocytes and synergizes with remdesivir to suppress infection.

Inducing Human Retinal Pigment Epithelium-like Cells from Somatic Tissue

This study develops a simplified method to induce RPE-like cells from human fibroblasts and validates their properties using single-cell RNA sequencing.

Efficacy of a novel SARS-CoV-2 detection kit without RNA extraction and purification

This study evaluates a new SARS-CoV-2 detection kit that skips RNA extraction and purification, showing high concordance with direct PCR across multiple sample types.