The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
C. Olivieri, Y. Wang, C. Walker, M. V. Subrahmanian, K. N. Ha, D. A. Bernlohr, J. Gao, C. Camilloni, M. Vendruscolo, S. S. Taylor, G. Veglia
This study identifies the αC-β4 loop as a key regulator of allosteric cooperativity between nucleotide and substrate in PKA-C through simulations and mutagenesis experiments.
eLife · Jun 24, 2024Peer-reviewedBiophysics