Author

T. J. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Animal Behavior & Cognition· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

A. E. Brown· 1 shared A. Jorgensen· 1 shared A. Marson· 1 shared A. Standke· 1 shared B. P. Koeleman· 1 shared C. Campbell· 1 shared C. Depondt· 1 shared C. Leu· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperAnimal Behavior & Cognition

A. E. Brown

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4 papers

Recent·Most cited

Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing

T. J. O'Brien, I. L. Barlow, L. Feriani, A. E. Brown

This study creates and phenotypes C. elegans models of Mendelian diseases to enable drug repurposing through high-throughput imaging and screening.

bioRxiv · Aug 25, 2023 · PreprintAnimal Behavior & Cognition

Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities

C. Campbell, D. Lewis-Smith, C. Leu, H. Martins, S. Wolking, R. Krause, T. J. O'Brien, G. Sills, F. Zara, B. P. Koeleman, C. Depondt, A. Marson, H. Stefansson, K. Stefansson, J. Craig, , G. Cavalleri

This study uses polygenic risk scores to show that people with epilepsy have increased genetic risk for depression, psychosis, and ADHD, with stronger associations in drug-resistant cases.

medRxiv · Jul 4, 2023 · PreprintGenetic & Genomic Medicine

The efficacy of antimicrobial agents is decreased in a polymicrobial environment

T. J. O'Brien, W. Figueroa, M. Welch

This study shows that antimicrobial efficacy decreases in polymicrobial cultures of CF-associated pathogens, with both phenotypic and genetic resistance mechanisms observed.

bioRxiv · Jul 20, 2021Microbiology

Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

J. L. Leslie, M. L. Jenior, K. C. Vendrov, A. Standke, M. R. Barron, T. J. O'Brien, L. Unverdorben, P. Thaprawat, I. L. Bergin, P. D. Schloss, V. B. Young

This study shows pre-colonization with a less virulent C. difficile strain reduces germination of a lethal strain by limiting glycine availability, offering a mechanism for protective intraspecies competition.

bioRxiv · Feb 26, 2021Microbiology