T. Kono

Lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: differential and interactive effects on novelty-induced hyperlocomotion, blood cytokine levels and TRL4-related processes

This study compares the effects of Porphyromonas gingivalis and Escherichia coli lipopolysaccharides on mouse behavior, cytokine levels, and TLR4 signaling, finding differential impacts on locomotion and cytokine responses.

Quantitative environmental DNA metabarcoding shows high potential as a novel approach to quantitatively assess fish community

This study evaluates the qMiSeq approach for quantitative eDNA metabarcoding to assess fish communities by comparing eDNA concentrations with capture survey results.

Estimation of biodiversity metrics by environmental DNA metabarcoding compared with visual and capture surveys of river fish communities

This study compares eDNA metabarcoding with visual and capture surveys to estimate alpha and gamma diversity in river fish communities, finding eDNA detects more species and provides broader regional insights.

Topoisomerase 2b induces DNA breaks to regulate human papillomavirus replication

This study shows that TOP2β induces DNA breaks to regulate HPV replication by interacting with CTCF/SMC1 at viral late regions, leading to DNA damage and impaired repair.

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer

This study develops a quantitative fitness model to analyze clonal dynamics in cancer under genetic and pharmacologic perturbations, revealing how mutations and drug resistance shape tumor evolution.

Relationships of trainee dentists’ empathy and communication characteristics with simulated patients’ assessment in medical interviews

This study examines how trainee dentists' empathy and communication styles affect simulated patients' assessments during medical interviews.