M. Cruz

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis

This study identifies the MadRS system and its operon madEFG as mediators of resistance to antimicrobial peptides and antibiotics in Enterococcus faecalis, linking membrane lipid changes to stress response and virulence.

Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes

This study shows that O-GlcNAc transferase (OGT) is downregulated in placenta tissues of women with gestational diabetes, especially with male fetuses, leading to GDM-like transcriptional changes.

Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 to drive osteoarthritis

This study identifies distinct synovial fibroblast subsets in PTOA and shows that Prg4hi fibroblasts secrete Rspo2 to drive pathological crosstalk.

Anti-SARS-CoV-2 hyperimmune immunoglobulin provides potent and robust neutralization capacity and antibody-dependent cellular cytotoxicity and phagocytosis induction through N and S proteins

This study evaluates the neutralization and antibody-dependent cellular effects of anti-SARS-CoV-2 hyperimmune immunoglobulin against multiple SARS-CoV-2 isolates and variants.

Production of anti-SARS-CoV-2 hyperimmune globulin from convalescent plasma

This paper describes the production of anti-SARS-CoV-2 hyperimmune globulin from convalescent plasma using a purification process, resulting in a highly purified IgG product with concentrated neutralizing antibodies.

Mitotic progression, arrest, exit or death is determined by centromere integrity and independent of de novo transcription

This study investigates the role of de novo transcription during mitosis and finds that centromere integrity, not transcription, determines mitotic progression, arrest, exit, or death.