Author

A.-M. Malfait

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

S. Ishihara· 4 shared A. M. Obeidat· 3 shared J. Li· 3 shared R. E. Miller· 3 shared M. J. Wood· 2 shared A. Montgomery· 1 shared A. Obeidat· 1 shared B. Eckman· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersPathology

S. Ishihara

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis

A. M. Obeidat, S. Y. Kim, K. G. Burt, B. Hu, J. Li, S. Ishihara, R. Xiao, R. E. Miller, C. B. Little, A.-M. Malfait, C. Scanzello

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

bioRxiv · Oct 14, 2023 · PreprintPathology

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury

R. F. Bergman, L. Lammlin, L. Junginger, E. Farrell, S. Goldman, R. Darcy, C. Rasner, A. M. Obeidat, A.-M. Malfait, R. Miller, T. Maerz

This study shows male mice have worse joint damage and persistent synovial inflammation after ACLR injury compared to females.

bioRxiv · Nov 30, 2022Physiology

Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice

T. Geraghty, A. Obeidat, S. Ishihara, M. J. Wood, J. Li, E. B. P. Lopes, C. R. Scanzello, T. M. Griffin, A.-M. Malfait, R. E. Miller

This study examines age-related changes in knee osteoarthritis, pain behaviors, and dorsal root ganglia immune profiles in male and female mice, revealing sex-specific differences in cartilage degeneration and immune cell composition.

bioRxiv · Jul 7, 2022Cell Biology

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis

A. M. Obeidat, M. J. Wood, S. Ishihara, J. Li, L. Wang, D. Ren, D. A. Bennett, R. J. Miller, A.-M. Malfait, R. E. Miller

This study shows that Piezo2 is essential for mechanical pain sensitization in osteoarthritis, as Piezo2-deficient mice are protected from mechanical hypersensitivity in two models.

bioRxiv · Mar 12, 2022Physiology

Macrophages drive the inflammatory phase in experimental osteoarthritis

A. Montgomery, N. Fahy, S. Hamilton, B. Eckman, L. De Almeida, S. Ishihara, M. G. Mayr, S.-Y. Chen, G. Gadhvi, C. Cuda, A.-M. Malfait, Y. Bastiaansen-Jenniskens, D. R. Winter

This study shows macrophages drive inflammation in early experimental osteoarthritis by expanding and altering their gene expression in mouse models.

bioRxiv · May 28, 2020 · PreprintImmunology