Author

T. Pantelejevs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:protein sequence· 1

Frequent Co-Authors

M. Hyvonen· 3 shared P. Zuazua-Villar· 2 shared A. J. Counsell· 1 shared C. F. Kaminski· 1 shared C. R. Cherry· 1 shared C. Talbot-Cooper· 1 shared D. R. Spring· 1 shared E. J. Rees· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

M. Hyvonen

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Author profile →

4 papers

Recent·Most cited

A Recombinant Approach For Stapled Peptide Discovery YieldsInhibitors of the RAD51 Recombinase

T. Pantelejevs, P. Zuazua-Villar, O. Koczy, A. J. Counsell, S. J. Walsh, N. S. Robertson, D. R. Spring, J. A. Downs, M. Hyvonen

This paper describes a recombinant approach for stapled peptide discovery and evaluates its effectiveness as inhibitors of the RAD51 recombinase.

bioRxiv · Feb 24, 2023Biochemistry

Divergent binding mode for a protozoan BRC repeat to RAD51

T. Pantelejevs, M. Hyvonen

The paper investigates the binding of two BRC repeats from Leishmania infantum BRCA2 to RAD51, revealing distinct binding modes and affinities compared to human BRC4.

bioRxiv · Jan 25, 2022Biochemistry

A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses

C. Talbot-Cooper, T. Pantelejevs, J. P. Shannon, C. R. Cherry, M. T. Au, M. Hyvönen, H. D. Hickman, G. L. Smith

This study identifies a poxvirus protein that inhibits STAT1 signaling by binding its SH2 domain, revealing a conserved mechanism across poxviruses and paramyxoviruses.

bioRxiv · Jul 17, 2021 · PreprintMicrobiology

Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats

L. Lindenburg, T. Pantelejevs, F. Gielen, P. Zuazua-Villar, M. Butz, E. J. Rees, C. F. Kaminski, J. Downs, M. Hyvonen, F. Hollfelder

The paper creates and tests chimeric BRC repeats to improve RAD51 binding, finding that shuffled modules can enhance binding affinity and function in human cells.

bioRxiv · May 14, 2020Biochemistry