Author

T. Polenova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:structural biology· 2 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

C. Xu· 2 shared J. R. Perilla· 2 shared R. Zadorozhnyi· 2 shared A. Engelman· 1 shared A. Kleinpeter· 1 shared A. M. Gronenborn· 1 shared B. K. Ganser-Pornillos· 1 shared B. Runge· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

C. Xu

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Structural Basis of HIV-1 Maturation Inhibitor Binding and Activity

S. Sarkar, K. K. Zadrozny, R. Zadorozhnyi, R. W. Russell, C. M. Quinn, A. Kleinpeter, S. Ablan, C. Xu, J. R. Perilla, E. O. Freed, B. K. Ganser-Pornillos, O. Pornillos, A. M. Gronenborn, T. Polenova

This study determines the structural basis of HIV-1 maturation inhibitor binding and resistance using NMR, revealing an allosteric mechanism and conformational changes in SP1 variants.

Nature Communications · Mar 4, 2023Peer-reviewedBiophysics

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

C. Xu, D. Fisher, S. Rankovic, W. Li, R. Dick, B. Runge, R. Zadorozhnyi, J. Ahn, C. Aiken, T. Polenova, A. Engelman, Z. Ambrose, I. Rousso, J. R. Perilla

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

bioRxiv · Apr 30, 2020Biophysics

Conformational Flexibility of p150Glued(1-191) Subunit of Dynactin Assembled with Microtubules

C. Guo, J. C. Williams, T. Polenova

This paper uses NMR spectroscopy to study the conformational flexibility of the p150Glued N-terminal region when bound to microtubules, revealing disordered regions and structural elements involved in microtubule binding.

bioRxiv · Apr 30, 2019Biophysics