Author

A. Engelman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Aiken· 2 shared C. Xu· 2 shared J. Ahn· 2 shared J. R. Perilla· 2 shared S. Jang· 2 shared Z. Ambrose· 2 shared A. Ballandras-Collas· 1 shared B. Runge· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

C. Aiken

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The mouse mammary tumor virus intasome exhibits distinct dynamics on target DNA

L. E. Baltierra-Jasso, N. D. Jones, A. Ballandras-Collas, A. Engelman, R. Fishel, K. E. Yoder

This study examines the biochemical and dynamic properties of the MMTV intasome, revealing its stability and distinct integration dynamics compared to PFV intasomes.

bioRxiv · Nov 17, 2021 · PreprintBiochemistry

A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid

Q. Shen, C. Xu, S. Jang, Q. Xiong, S. Devarkar, T. Tian, G. Bedwell, T. Tripler, Y. Hu, S. Yuan, J. Temple, J. Shi, C. Aiken, A. Engelman, J. R. Perilla, , Y. Xiong

This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.

bioRxiv · Aug 10, 2020 · PreprintMicrobiology

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner

Z. Zhong, J. Ning, E. A. Boggs, S. Jang, C. Wallace, C. Telmer, M. Bruchez, J. Ahn, A. Engelman, p. zhang, S. C. Watkins, Z. Ambrose

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

bioRxiv · Jun 5, 2020Microbiology

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

C. Xu, D. Fisher, S. Rankovic, W. Li, R. Dick, B. Runge, R. Zadorozhnyi, J. Ahn, C. Aiken, T. Polenova, A. Engelman, Z. Ambrose, I. Rousso, J. R. Perilla

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

bioRxiv · Apr 30, 2020Biophysics