O. Pornillos

Arg18 substitutions reveal the capacity of the HIV-1 capsid protein for non-fullerene assembly

The paper shows that Arg18 substitutions in HIV-1 capsid protein lead to non-fullerene capsid assembly with unique structural features.

Structural Basis of HIV-1 Maturation Inhibitor Binding and Activity

This study determines the structural basis of HIV-1 maturation inhibitor binding and resistance using NMR, revealing an allosteric mechanism and conformational changes in SP1 variants.

A molecular switch modulates assembly and host factor binding of the HIV-1 capsid

This study identifies a molecular switch in HIV-1 capsid protein that controls capsid assembly and host factor binding, and is a target for the inhibitor lenacapavir.

Strain and rupture of HIV-1 capsids during uncoating

This study uses molecular dynamics simulations and cryo-ET to show HIV-1 capsids exhibit strain patterns and rupture via crack propagation along high-strain regions.

Poly(ADP-ribose) potentiates ZAP antiviral activity

This study shows that poly(ADP-ribose) enhances ZAP's ability to degrade viral RNA by binding to ZAP's WWE domains, improving its antiviral activity against HIV-1.

Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

This study shows that destabilizing the HIV-1 capsid lattice leads to premature loss of the viral genome and integrase enzyme in infected cells.

Vesicular stomatitis virus transcription is inhibited by TRIM69 in the interferon-induced antiviral state

This study identifies TRIM69 as an IFN-induced antiviral factor that inhibits VSVIND replication by targeting its phosphoprotein P through a novel transcriptional inhibition mechanism.