Author

T. Radaszkiewicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

V. Bryja· 3 shared B.-K. Koo· 2 shared D. Potesil· 2 shared I. Jordens· 2 shared M. M. Maurice· 2 shared Z. Zdrahal· 2 shared A. Catala-Bordes· 1 shared A. Merenda· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

V. Bryja

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

G. Colozza, H. Lee, A. Merenda, S.-H. Wu, A. Catala-Bordes, T. Radaszkiewicz, I. Jordens, J.-H. Lee, A.-D. Bamford, F. Farnhammer, T. Y. Low, M. M. Maurice, V. Bryja, J. Kim, B.-K. Koo

This study identifies Daam1/2 as a regulator of Wnt signaling that is essential for Paneth cell differentiation and intestinal stem cell homeostasis.

bioRxiv · Jan 24, 2023Cell Biology

RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion

T. Radaszkiewicz, M. Noskova, K. Gömöryova, O. Vondalova Blanarova, K. A. Radaszkiewicz, M. Pickova, R. Vichova, T. Gybel, K. Kaiser, L. Demkova, L. Kucerova, D. Potesil, Z. Zdrahal, K. Soucek, V. Bryja

This study shows RNF43 inhibits WNT5A signaling and suppresses melanoma invasion by ubiquitinating VANGL2 and internalizing ROR1, leading to worse prognosis in RNF43-low patients.

bioRxiv · Feb 8, 2021Cancer Biology

RNF43 truncating mutations mediate a tumour suppressor-to-oncogene switch to drive niche-independent self-renewal in cancer

M. Spit, N. Fenderico, I. Jordens, T. Radaszkiewicz, R. G. H. Lindeboom, J. M. Bugter, L. Ootes, M. van Osch, E. Janssen, K. E. Boonekamp, K. Hanakova, D. Potesil, Z. Zdrahal, S. F. Boj, J. P. Medema, , M. M. Maurice

This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.

bioRxiv · Sep 1, 2019Cancer Biology