Author

J. P. Medema

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Erozenci· 1 shared A. Valles Marti· 1 shared B.-K. Koo· 1 shared C. R. Jimenez· 1 shared D. Dekker· 1 shared D. J. Huels· 1 shared D. Potesil· 1 shared E. Giovannetti· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. Erozenci

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Large pan-cancer cell screen coupled to (phospho-) proteomics underscores high-dose vitamin C as a potent anti-cancer agent

A. Valles Marti, F. Böttger, E. Yau, K. Tejjani, L. Meijs, S. Sharma, M. Mumtaz, T. Le Large, A. Erozenci, D. Dekker, T. Schelfhorst, J. P. Medema, I. V. Bijnsdorp, J. C. Knol, S. R. Piersma, , C. R. Jimenez

This study evaluates high-dose vitamin C's anti-cancer effects across 51 cancer cell lines, finding high sensitivity and proteomic changes linked to cell cycle and immune pathways.

bioRxiv · Dec 19, 2023 · PreprintCancer Biology

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult gut

R. Ramadan, S. M. van Neerven, V. M. Wouters, T. Martins Garcia, V. Muncan, O. D. Franklin, M. Battle, K. S. Carlson, J. Leach, O. J. Sansom, L. Vermeulen, J. P. Medema, D. J. Huels

This study shows that extracellular matrix components, specifically laminin, control stem cell specification and crypt morphology in the gut, with laminin promoting adult stem cell features and crypt-like structures.

bioRxiv · Apr 14, 2021Cell Biology

RNF43 truncating mutations mediate a tumour suppressor-to-oncogene switch to drive niche-independent self-renewal in cancer

M. Spit, N. Fenderico, I. Jordens, T. Radaszkiewicz, R. G. H. Lindeboom, J. M. Bugter, L. Ootes, M. van Osch, E. Janssen, K. E. Boonekamp, K. Hanakova, D. Potesil, Z. Zdrahal, S. F. Boj, J. P. Medema, , M. M. Maurice

This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.

bioRxiv · Sep 1, 2019Cancer Biology