R. Hurwitz

Tyrosine halogenation converts α-defensins into potent immunomodulators

The paper identifies that tyrosine halogenation of α-defensins by hypohalous acids converts them into immunomodulatory mediators, revealing a novel oxidative mechanism in neutrophil function.

Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in Drosophila

This study identifies mechanisms by which gut commensals resist host antimicrobial peptides during infection and aging in Drosophila.

PEGylated recombinant Aplysia punctata ink toxin depletes arginine and lysine and inhibits growth of tumor xenografts

This study shows that PEGylated APIT reduces tumor growth in xenograft models by depleting arginine and lysine through amino acid oxidation.

The Aryl Hydrocarbon Receptor senses the Henna pigment Lawsone and mediates Yin-Yang effects on skin homeostasis

This study shows that Lawsone, a Henna pigment, activates the AhR receptor in skin cells, with both beneficial and harmful effects depending on the physiological context.

ADP heptose, a novel pathogen-associated molecular pattern associated with Helicobacter pylori type 4 secretion

The paper identifies ADP heptose as the key PAMP in Helicobacter pylori that activates NF-κB via the Alpk1-TIFA axis, showing 100-fold stronger activity than previously proposed HBP.