J. Schlegel

Human cerebral assembloids as a model to study the interaction of glioblastoma with resident glial cells

This study develops human cerebral assembloids to model glioblastoma interactions with glial cells, revealing extracellular vesicles' role in peritumoral niche formation.

VISION -- an open-source software for automated multi-dimensional image analysis of cellular biophysics

VISION is an open-source software for automated multi-dimensional image analysis of cellular biophysics, enabling high throughput and correlative analysis of biophysical properties.

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

This study identifies virapinib, a novel inhibitor of macropinocytosis that blocks viral entry by SARS-CoV-2, Monkeypox virus, and TBEV without host cell toxicity.

Quantifying fluorescence lifetime responsiveness of environment sensitive probes for membrane fluidity measurements

The paper quantifies how fluorescence lifetime responds to environmental changes in membrane order probes and highlights their sensitivity to biophysical properties.

Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry

The paper reveals that mammalian plasma membranes have phospholipid imbalances due to cholesterol asymmetry, affecting membrane permeability and protein localization.

Single particle profiler for measuring content and properties of nano-sized bioparticles

The paper introduces a high-throughput method called single particle profiler (SPP) to analyze content and biophysical properties of nanoscale bioparticles, demonstrating its application on mRNA encapsulation, viral binding, and biophysical heterogeneity.

Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways

This study identifies two CLE peptide signaling pathways that regulate Arabidopsis shoot stem cell homeostasis through antagonistic feedback loops involving WUS expression.

The cell fate controlling CLE40 peptide requires CNGC9 to trigger highly localized Ca2+ transients in Arabidopsis thaliana root meristems

This study identifies CNGC9 as essential for CLE40-induced Ca2+ transients in Arabidopsis root meristems, linking peptide signaling to cell fate regulation.

Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy

This study uses sphingolipid expansion microscopy to image bacterial infections at nanoscale resolution, revealing details of intracellular bacterial membranes previously only accessible via electron microscopy.

Carbon ion dosimetry on a fluorescent nuclear track detector using widefield microscopy

This paper demonstrates that widefield microscopy can efficiently read out fluorescent nuclear track detectors after carbon ion irradiation, offering a faster alternative to laser scanning confocal microscopy.

The biomedical sensor Cell-Fit-HD4D, reveals individual tumor cell fate in response to microscopic ion deposition.

The paper introduces a biomedical sensor, Cell-Fit-HD4D, to monitor individual tumor cell fate after ion beam therapy and demonstrates its ability to visualize ion beams and track cell responses.