T. S. Rasmussen

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

This study develops modified fecal virome transplants (FVT) to reduce donor variability and infection risks in treating C. difficile infections, showing improved efficacy and safety in a mouse model.

Choice of Ultrafilter affects Recovery Rate of Bacteriophages

The paper investigates how the choice of ultrafilter affects the recovery of bacteriophages from clinical samples, finding that pore size influences recovery strain- and sample-dependently.

Transfer of modified fecal viromes improve blood glucose regulation and alleviates symptoms of metabolic dysfunction-associated fatty liver disease in an obesity male mouse model

Modified fecal virome transplantation improves blood glucose regulation in obese mice without reducing weight gain, while unmodified FVT reduces immune cell proportions in adipose tissue.

Reproducible chemostat cultures to eliminate eukaryotic viruses from fecal transplant material

This study shows that continuous chemostat cultures reduce eukaryotic viruses in fecal material, suggesting a safer alternative to fecal microbiota transplantation.

Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice

This study shows that fecal virome transplantation increases Akkermansia muciniphila abundance in mice and unexpectedly raises fertility rates in co-housed pairs.

CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice

This study shows that the CRISPR-Cas system of Eggerthella lenta provides limited phage immunity in vitro and in vivo, allowing coexistence of phage and bacteria in the gut.

Faecal virome transplantation decrease symptoms of type-2-diabetes and obesity in a murine model

This study shows that faecal virome transplantation from lean donors reduces weight gain and improves glucose tolerance in obese mice, suggesting a role for gut viruses in metabolic health.

Sporaefaciens musculi gen. nov., sp. nov., a novel bacterium isolated from the caecum of an obese mouse

The paper isolates and characterizes a novel bacterium from an obese mouse's caecum, proposing a new genus and species based on genomic and phenotypic data.

Mouse vendor influence on the bacterial and viral gut composition exceeds the effect of diet

This study shows that differences between mouse vendors have a greater impact on gut bacterial and viral communities than diet.