A. K. Hansen

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

This study develops modified fecal virome transplants (FVT) to reduce donor variability and infection risks in treating C. difficile infections, showing improved efficacy and safety in a mouse model.

Megabarcoding reveals a tale of two very different dark taxa along the same elevational gradient

The paper uses megabarcoding to show that two Diptera taxa have distinct spatio-temporal distributions along an elevational gradient in a temperate forest.

Investigating the Rescue Potential of Fecal Microbiota Transplants in Anorexia Nervosa using Antibiotic-treated Mice in a Split Group Cross-Over Study

This study examines the effects of fecal microbiota transplants from anorexia nervosa patients on mice, showing altered food intake and appetite hormones, which may be improved with transplants from healthy donors.

Express barcoding with NextGenPCR and MinION for species-level sorting of ecological samples

This paper introduces a rapid, low-cost barcoding workflow using NextGenPCR and MinION sequencers to identify species in ecological samples within 6 hours.

Transfer of modified fecal viromes improve blood glucose regulation and alleviates symptoms of metabolic dysfunction-associated fatty liver disease in an obesity male mouse model

Modified fecal virome transplantation improves blood glucose regulation in obese mice without reducing weight gain, while unmodified FVT reduces immune cell proportions in adipose tissue.

Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice

This study shows that fecal virome transplantation increases Akkermansia muciniphila abundance in mice and unexpectedly raises fertility rates in co-housed pairs.

CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice

This study shows that the CRISPR-Cas system of Eggerthella lenta provides limited phage immunity in vitro and in vivo, allowing coexistence of phage and bacteria in the gut.

Synthetic Photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to Body Mass Index (BMI)

The paper develops a synthetic PPG model of the radial artery and shows BMI correlates with PPG signal degradation.

Faecal virome transplantation decrease symptoms of type-2-diabetes and obesity in a murine model

This study shows that faecal virome transplantation from lean donors reduces weight gain and improves glucose tolerance in obese mice, suggesting a role for gut viruses in metabolic health.

Multi-photon attenuation-compensated light-sheet fluorescence microscopy

This paper introduces a method to improve depth penetration in multi-photon light-sheet fluorescence microscopy using a graded neutral density filter, benchmarked against a spatial light modulator system.

Mouse vendor influence on the bacterial and viral gut composition exceeds the effect of diet

This study shows that differences between mouse vendors have a greater impact on gut bacterial and viral communities than diet.