D. S. Nielsen

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

This study develops modified fecal virome transplants (FVT) to reduce donor variability and infection risks in treating C. difficile infections, showing improved efficacy and safety in a mouse model.

A single strand-based library preparation method for unbiased virome characterization

This paper introduces a single-stranded library preparation method for virome characterization, showing improved accuracy and reduced bias compared to existing methods.

Gut microbial-mediated polyphenol metabolism is restrained by parasitic whipworm infection and associated with altered immune function in mice

This study shows that polyphenol intake interacts with parasitic whipworm infection in mice, altering immune responses and gut microbial metabolism.

Choice of Ultrafilter affects Recovery Rate of Bacteriophages

The paper investigates how the choice of ultrafilter affects the recovery of bacteriophages from clinical samples, finding that pore size influences recovery strain- and sample-dependently.

The effect of colonic pH on microbial activity and metabolite production using common prebiotics as substrates: an in vitro study

This study examines how colonic pH affects gut microbial composition and metabolite production using prebiotics in an in vitro setup, finding that higher pH promotes SCFA production.

Transfer of modified fecal viromes improve blood glucose regulation and alleviates symptoms of metabolic dysfunction-associated fatty liver disease in an obesity male mouse model

Modified fecal virome transplantation improves blood glucose regulation in obese mice without reducing weight gain, while unmodified FVT reduces immune cell proportions in adipose tissue.

Reproducible chemostat cultures to eliminate eukaryotic viruses from fecal transplant material

This study shows that continuous chemostat cultures reduce eukaryotic viruses in fecal material, suggesting a safer alternative to fecal microbiota transplantation.

The influence of early life exposures on the infant gut virome

This study investigates how early life factors influence the gut virome composition in infants, identifying environmental exposures that shape viral communities and their potential metabolic impacts.

Dietary non-starch polysaccharides impair immunity to enteric nematode infection

This study shows that high levels of non-starch polysaccharides in diet impair type-2 immunity and increase susceptibility to enteric helminth infections in mice.

Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice

This study shows that fecal virome transplantation increases Akkermansia muciniphila abundance in mice and unexpectedly raises fertility rates in co-housed pairs.

CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice

This study shows that the CRISPR-Cas system of Eggerthella lenta provides limited phage immunity in vitro and in vivo, allowing coexistence of phage and bacteria in the gut.

Dietary Proanthocyanidins Exert Localized Immunomodulatory Effects in Porcine Pulmonary and Gastrointestinal Tissues during Ascaris suum-induced Type 2 inflammation

This study shows that dietary proanthocyanidins enhance intestinal immune and antioxidant responses but have limited effects on pulmonary type-2 inflammation during Ascaris suum infection in pigs.

Parasite-probiotic interactions in the gut: Bacillus sp. and Enterococcus faecium regulate type-2 inflammatory responses and modify the gut microbiota of pigs during helminth infection

This study examines how probiotic mixtures affect helminth infection and gut microbiota in pigs, finding that BBE modulates type-2 inflammation and microbiota but not infection levels.

Hundreds of viral families in the healthy infant gut

This study manually resolves viral dark matter in a large infant gut virome dataset, identifying over ten thousand viral species across 248 families and expanding bacteriophage taxonomy.

Prophages in the infant gut are largely induced, and may be functionally relevant to their hosts.

This study identifies prophages in infant gut metagenomes, showing they are largely induced and may influence microbiome dynamics through functional elements.

The phytonutrient cinnamaldehyde limits intestinal inflammation and enteric parasite infection

This study shows that cinnamaldehyde reduces intestinal inflammation and improves resistance to enteric parasite infection in mice, independent of gut microbiota.

A bacteriophage cocktail significantly reduces Listeria monocytogenes without deleterious impact on the commensal gut microbiota under simulated gastro-intestinal conditions

This study shows a bacteriophage cocktail (FOP) reduces Listeria monocytogenes in simulated gut conditions without harming commensal bacteria, outperforming ampicillin in some aspects.

Supplementation of a lacto-fermented rapeseed-seaweed blend promotes gut microbial- and gut immune-modulation in weaner piglets

This study shows that a lacto-fermented rapeseed-seaweed blend improves gut health and microbiota composition in weaner piglets, with no additional benefit from increasing the blend's dietary inclusion beyond 2.5%.

Fecal filtrate transfer protects against necrotizing enterocolitis in preterm pigs

This study shows that fecal filtrate transfer prevents necrotizing enterocolitis in preterm pigs without side effects, while fecal microbiota transplantation does not.

Gut Mycobiome Dysbiosis Is Linked to Hypertriglyceridemia among Home Dwelling Elderly Danes

This study links gut mycobiome dysbiosis to hypertriglyceridemia in elderly Danes by analyzing dietary intake, fungal composition, and metabolomic data.

Faecal virome transplantation decrease symptoms of type-2-diabetes and obesity in a murine model

This study shows that faecal virome transplantation from lean donors reduces weight gain and improves glucose tolerance in obese mice, suggesting a role for gut viruses in metabolic health.

Physical fitness in community dwelling older adults is linked to dietary intake, gut microbiota and metabolomic signatures

The paper links physical fitness in older adults to dietary intake, gut microbiota, and metabolomic signatures, identifying key factors explaining individual variation in fitness.

Characterization of the vaginal DNA virome in health and dysbiosis: an opening study in patients with non-female factor infertility

This study characterizes the vaginal DNA virome in patients with non-female factor infertility and finds associations between viral community composition and bacterial dysbiosis.

Sporaefaciens musculi gen. nov., sp. nov., a novel bacterium isolated from the caecum of an obese mouse

The paper isolates and characterizes a novel bacterium from an obese mouse's caecum, proposing a new genus and species based on genomic and phenotypic data.

Housing temperature influences exercise training adaptations in mice

This study shows that housing mice at thermoneutral temperatures reduces exercise training benefits in metabolic parameters and tissue adaptations.

Mouse vendor influence on the bacterial and viral gut composition exceeds the effect of diet

This study shows that differences between mouse vendors have a greater impact on gut bacterial and viral communities than diet.

The smallest intestine (TSI) - a low volume in vitro model of the small intestine with increased throughput

The paper develops a low-volume in vitro model of the small intestine (TSI) to study probiotic survival, showing that ileal microbiota significantly impacts probiotic survival.