A. Brunse

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

This study develops modified fecal virome transplants (FVT) to reduce donor variability and infection risks in treating C. difficile infections, showing improved efficacy and safety in a mouse model.

A weighted and cumulative point system for accurate scoring of intestinal pathology in a piglet model of necrotizing enterocolitis

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

This study shows that reducing glucose supply during infection improves survival in preterm infants by decreasing inflammation and maintaining normoglycemia, with liver involvement in these protective effects.

Transfer of modified fecal viromes improve blood glucose regulation and alleviates symptoms of metabolic dysfunction-associated fatty liver disease in an obesity male mouse model

Modified fecal virome transplantation improves blood glucose regulation in obese mice without reducing weight gain, while unmodified FVT reduces immune cell proportions in adipose tissue.

Parenteral glucose supply and pharmacological glycolysis inhibition determine the clinical fate of infected preterm newborns

This study shows that high parenteral glucose during infection in preterm infants leads to sepsis, while glucose restriction prevents it, highlighting the role of glucose in immune response.

Fecal filtrate transfer protects against necrotizing enterocolitis in preterm pigs

This study shows that fecal filtrate transfer prevents necrotizing enterocolitis in preterm pigs without side effects, while fecal microbiota transplantation does not.